Background: Dengue is a major mosquito-borne viral infection with increasing prevalence globally, particularly in tropical regions. The clinical presentation varies from mild febrile illness to severe complications such as Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Objectives: To evaluate the clinical profile of dengue patients and identify predictors of severity, enabling early management and prevention of complications. Methods: A prospective observational study on 120 dengue-positive patients admitted to a tertiary care hospital. Clinical features, hematological parameters, liver function tests, and warning signs were recorded and analyzed. Results: Fever (100%), headache (72%), myalgia (68%), and rash (48%) were common symptoms. Thrombocytopenia was present in 94% of patients. Severe dengue was significantly associated with elevated hematocrit, persistent vomiting, abdominal pain, liver dysfunction, and platelet count <50,000/µL. Conclusion: Certain clinical and laboratory factors such as thrombocytopenia, high hematocrit, elevated liver enzymes, and warning signs can predict severity and help in timely intervention to reduce morbidity and mortality.