Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired infections (HAIs) worldwide, posing a challenge due to its resistance to multiple antibiotics. Objectives: To determine the prevalence of MRSA in hospitalized patients, evaluate associated risk factors, and assess antibiotic sensitivity patterns. Methods: A cross-sectional study was conducted over 12 months, including 300 patients with suspected hospital infections. Clinical samples were processed, and MRSA was identified using cefoxitin disc diffusion method. Antibiotic susceptibility testing was performed. Results: MRSA was isolated in 32% of all Staphylococcus aureus cultures. Highest prevalence was seen in ICU patients (48%) and surgical wards (40%). Major risk factors were prolonged hospital stay, invasive procedures, prior antibiotic usage, and diabetes. Linezolid and vancomycin showed highest sensitivity. Conclusion: MRSA prevalence remains high in tertiary care hospitals. Strict infection control, antibiotic stewardship, and screening of highrisk patients are essential to prevent its spread.