Background: Chronic Kidney Disease (CKD) is associated with disturbances in electrolyte balance due to impaired renal function and reduced excretion. Electrolyte abnormalities contribute significantly to morbidity and mortality in CKD patients. Aim: To evaluate the pattern of electrolyte imbalance in CKD patients and correlate it with the stages of CKD. Methods: A cross-sectional observational study was conducted on 200 diagnosed CKD patients (stages 2–5). Serum levels of sodium, potassium, calcium, and phosphate were measured and correlated with CKD stage, duration of illness, and clinical manifestations. Results: Hyperkalemia (46%) and hyponatremia (38%) were the most common electrolyte abnormalities. Hypocalcemia (32%) and hyperphosphatemia (28%) were observed mainly in stage IV and V CKD. Severe electrolyte imbalance was associated with arrhythmias, muscle weakness, and altered sensorium. Conclusion: Electrolyte imbalance is highly prevalent in CKD, especially in advanced stages. Regular monitoring and