Background: Psoriasis is a chronic immune-mediated inflammatory dermatosis with variable clinical presentations and psychological burden. Multiple therapies exist, including topical agents, phototherapy, and systemic drugs, with varying treatment responses. Aim: To study clinical patterns of psoriasis and evaluate treatment outcomes of various therapeutic modalities. Methods: A prospective observational study was conducted on 100 diagnosed cases of psoriasis over 12 months. Detailed history, screening for comorbidities, clinical examination, PASI scoring (Psoriasis Area Severity Index), treatment selection, and response assessment were carried out. Results: Plaque psoriasis was the most common type (72%), followed by guttate (12%), erythrodermic (8%), and pustular psoriasis (8%). Topical corticosteroids showed good response in mild cases (PASI reduction >50% in 85%). Methotrexate provided significant improvement in moderate-to-severe cases (PASI reduction >70% in 68%). Biologics (adalimumab) showed the highest response (PASI reduction >90%) but were limited due to cost. Conclusion: Treatment outcome depended on severity, comorbidities, and adherence. Early diagnosis and individualized therapy significantly improve quality of life in psoriasis patients.