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Vitamin D Deficiency And Its Association With Hypertension

Author(s): Wei Zhang , Li Zhang , Zhang Wei

Cite this article as: Wei Zhang1 , Li Zhang , Zhang Wei

DOI:10.5281/zenodo.17636567

Background: Vitamin D deficiency has been implicated in multiple non-skeletal conditions including cardiovascular disease and hypertension. Several observational studies suggest an inverse relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and blood pressure, but evidence remains inconsistent. Aim: To determine the prevalence of vitamin D deficiency in an adult population and examine its association with blood pressure and prevalence of hypertension. Methods: This cross-sectional study enrolled 600 adults (age 25–70 years) attending general outpatient clinics between January– December 2023. Serum 25(OH)D, systolic and diastolic blood pressure (SBP, DBP), fasting glucose, BMI and lipid profile were measured. Vitamin D status: sufficient ≥30 ng/mL, insufficient 20–29 ng/mL, deficient <20 ng/mL. Hypertension was defined as SBP ≥140 mmHg and/or DBP ≥90 mmHg or current antihypertensive therapy. Statistical analysis included chi-square, t-tests, ANOVA and multivariable logistic regression to adjust for confounders. Results: Mean age was 46.8 ± 11.4 years; 54% female. Vitamin D deficiency was present in 44.5% (n=267), insufficiency in 31.0% (n=186), and sufficient levels in 24.5% (n=147). Overall hypertension prevalence was 29.8% (n=179). Hypertension prevalence by vitamin D category: deficient 38.2%, insufficient 28.5%, sufficient 17.0% (p < 0.001). Mean SBP/DBP were higher in deficient group (SBP 136.4 ± 15.8 mmHg; DBP 86.7 ± 9.7 mmHg) than in sufficient group (SBP 126.1 ± 12.3; DBP 78.2 ± 8.4) (p < 0.001). After adjustment for age, sex, BMI, diabetes, and lipid profile, vitamin D deficiency remained independently associated with hypertension (adjusted OR 1.87; 95% CI 1.22–2.86; p = 0.004). Conclusion: Vitamin D deficiency is common in this urban adult sample and is independently associated with higher blood pressure and greater odds of hypertension. Screening for vitamin D status and controlled trials of supplementation are warranted to test whether correction reduces blood pressure in deficient individuals.

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Wei Zhang

Li Zhang

Zhang Wei

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